{"product_id":"subitene-400-mg-granulato-per-soluzione-orale12-bustine","title":"SUBITENE \"400 MG GRANULES FOR ORAL SOLUTION\" 12 SACHETS\"","description":"\u003cb\u003eName\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eSUBITENE 400 mg granules for oral solution\u003c\/b\u003e\u003cbr\u003e Ibuprofen\u003cbr\u003e Equivalent medicine\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eWhat is it and what is it used for?\u003c\/b\u003e\u003cbr\u003e SUBITENE contains ibuprofen, which belongs to a class of medicines called NSAIDs (nonsteroidal anti-inflammatory drugs). These medicines work by reducing pain and swelling caused by inflammation and fever.\u003cbr\u003e SUBITENE is used to treat pain of various origins and natures: headache, toothache, neuralgia, muscle and bone pain (muscular and osteoarticular), and menstrual pain. SUBITENE is also indicated as an adjunct in the treatment of fever and flu symptoms.\u003cbr\u003e\u003cbr\u003e Talk to your doctor if you do not feel better or if you feel worse after a short time of treatment.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eWhat you need to know before taking the medicine\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eDo not take SUBITENE:\u003c\/b\u003e \u003cbr\u003e- if you are allergic to ibuprofen, other similar anti-inflammatory medicines (e.g. acetylsalicylic acid) or any of the other ingredients of this medicine (listed in section 6);\u003cbr\u003e - if you have had an ulcer or bleeding in the stomach or intestine (active gastroduodenal ulcer) or if you suffer from other stomach problems (gastropathies);\u003cbr\u003e - if you have suffered in the past from stomach and intestinal disorders associated with bleeding (gastrointestinal bleeding, perforation related to previous active treatments or history of bleeding, recurrent peptic ulcer, with two or more distinct episodes of proven ulceration or bleeding);\u003cbr\u003e - if you suffer from severe liver or kidney problems (severe liver or kidney failure);\u003cbr\u003e - if you suffer from severe heart problems (severe heart failure);\u003cbr\u003e - if you are in the last three months of pregnancy or if you are breastfeeding (See section \"Pregnancy and breastfeeding\"); \u003cbr\u003e- if you have significant dehydration (caused by vomiting, diarrhea or insufficient fluid consumption);\u003cbr\u003e - if the person who is to take the medicine is a child under 12 years of age;\u003cbr\u003e - if you suffer from a condition called phenylketonuria (see the section \"SUBITENE contains sucrose, sodium, potassium and aspartame\").\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003eWarnings and precautions\u003c\/b\u003e\u003cbr\u003e Talk to your doctor or pharmacist before taking SUBITENE.\u003cbr\u003e\u003cbr\u003e Take this medicine \u003cb\u003ewith caution\u003c\/b\u003e and after consulting your doctor in the following situations:\u003cbr\u003e • if you suffer from chronic inflammatory bowel diseases such as inflammation of the colon with ulcers (ulcerative colitis), inflammation of the digestive tract (Crohn's disease);\u003cbr\u003e • if you suffer from problems with your normal blood clotting mechanism. SUBITENE may prolong bleeding time; \u003cbr\u003e• if you have previously experienced breathing difficulties due to narrowing of the airways (bronchospasm) following the taking of medicines used to treat inflammation (non-steroidal anti-inflammatory drugs);\u003cbr\u003e • if you suffer from breathing problems (asthma), chronic rhinitis or current or previous allergic diseases;\u003cbr\u003e • if you have liver, kidney, heart problems or high blood pressure;\u003cbr\u003e • if you are taking other anti-inflammatory medicines (including selective COX-2 inhibitors);\u003cbr\u003e • if the patient is an adolescent and is dehydrated;\u003cbr\u003e • if you suffer from a condition called phenylketonuria (see the section \"SUBITENE contains sorbitol, sucrose, sodium, potassium and aspartame\");\u003cbr\u003e • if you have an infection (see section \"Infections\" below).\u003cbr\u003e   \u003cbr\u003eSigns of an allergic reaction to ibuprofen have been reported, including breathing problems, swelling of the face and neck (angioedema), and chest pain. Stop taking Subitene immediately and contact your doctor or emergency medical services immediately if you notice any of these signs.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eInform\u003c\/b\u003e your doctor in the following cases: \u003cbr\u003e- if you experience any \u003cb\u003eunusual abdominal symptoms\u003c\/b\u003e , especially if these symptoms occur at the start of treatment. The risk of \u003cb\u003ebleeding\u003c\/b\u003e or \u003cb\u003eulceration\u003c\/b\u003e of the digestive tract is higher in this case, especially if you are elderly, if you take high doses of this medicine, or if you take other medicines (see the section \"Other medicines and SUBITENE\"). If bleeding or ulceration of the digestive tract occurs, treatment must be stopped because they can be fatal. You should be particularly careful if you have had a gastric or intestinal ulcer, particularly if it was complicated by perforation or accompanied by bleeding; \u003cbr\u003e- if you suffer from heart problems, have had a stroke, or think you may be at risk of developing these conditions (for example, if you have high blood pressure, diabetes, or high cholesterol, or are a smoker). This medicine may increase the risk of heart attack (myocardial infarction) or stroke, especially if you take high doses or for prolonged periods. Never exceed the recommended dose or duration of treatment. Be especially careful if you take this medicine at high doses (2400 mg per day) or for prolonged treatment, as it may increase the risk of heart problems (stroke and heart attack);\u003cbr\u003e - if you are undergoing prolonged treatment with this medicine or suffer from diffuse lupus erythematosus, your doctor will have to periodically check your kidneys; \u003cbr\u003e- if you experience leg swelling (edema), heart problems (heart failure), or high blood pressure, which may be symptoms of kidney problems. SUBITENE can cause kidney problems, especially in elderly people or those with existing kidney, heart, or liver problems, or those taking diuretics or ACE inhibitors. Stop treatment if kidney problems occur.\u003cbr\u003e\u003cbr\u003e This medicine \u003cb\u003emay cause\u003c\/b\u003e :\u003cbr\u003e - eye problems. If you take this medicine for prolonged periods, have your eyes checked regularly;\u003cbr\u003e - brain problems (aseptic meningitis) on rare occasions. This can occur mainly in people suffering from diseases such as systemic lupus erythematosus and related connective tissue diseases, but it has also been observed in patients without concomitant chronic diseases;\u003cbr\u003e - permanent kidney damage, with risk of kidney failure. This may happen if you regularly take this medicine; \u003cbr\u003e- allergic reactions (hypersensitivity reactions), including severe ones (anaphylactoid reactions). The risk increases if you have previously suffered from these problems after taking anti-inflammatory drugs (analgesics, antipyretics, NSAIDs) or if you suffer from asthma, rhinitis, hay fever, or other conditions (nasal polyps, chronic obstructive pulmonary disease, angioedema; see the section \"Do not take SUBITENE\"). Allergic reactions may appear as breathing difficulties (analgesic asthma) or as skin rashes (urticaria, Quincke's edema). Discontinue treatment at the first signs of an allergic reaction.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eInfections\u003c\/b\u003e \u003cbr\u003eSubitene may mask the symptoms of infections such as fever and pain. Therefore, Subitene may delay adequate treatment of the infection, which could increase the risk of complications. This has been observed in pneumonia caused by bacteria and bacterial skin infections related to chickenpox. If you take this medicine while you have an infection and the symptoms persist or worsen, contact your doctor immediately.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eTake special care with Subitene\u003c\/b\u003e \u003cbr\u003eSerious skin reactions, including exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP), have been reported in association with ibuprofen treatment. Stop using Subitene and contact your doctor immediately if you notice any of the symptoms related to these serious skin reactions described in section 4.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eChildren and adolescents\u003c\/b\u003e\u003cbr\u003e This medicine is not recommended for children under 12 years of age.\u003cbr\u003e Kidney damage may occur in dehydrated children and adolescents.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eElderly people\u003c\/b\u003e\u003cbr\u003e If you are elderly, you may be more susceptible to side effects, particularly bleeding and perforation of the digestive tract, which can be fatal.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e \u003cb\u003ePossible side effects\u003c\/b\u003e \u003cbr\u003eLike all medicines, this medicine can cause side effects, although not everybody gets them.\u003cbr\u003e\u003cbr\u003e Stop treatment with SUBITENE and contact your doctor immediately if you experience the following side effects:\u003cbr\u003e - formation of lesions in the stomach or intestines (peptic ulcers, perforation or gastrointestinal bleeding, sometimes fatal), especially in elderly people;\u003cbr\u003e - feeling of heaviness in the stomach, nausea, vomiting, diarrhoea, flatulence, constipation, digestive disorders (dyspepsia), abdominal pain, presence of blood in the stools (melena) and in vomit (haematemesis);\u003cbr\u003e - mouth infection with formation of lesions (ulcerative stomatitis);\u003cbr\u003e - worsening of some intestinal disorders (colitis and Crohn's disease);\u003cbr\u003e - increased risk of heart problems (stroke and heart attack), especially if you take this medicine in high doses and for prolonged treatment; \u003cbr\u003e- exacerbation of infection-related inflammation has been described (e.g. development of necrotizing fasciitis);\u003cbr\u003e - flat, target-shaped or circular reddish patches on the trunk, often with central vesicles, peeling skin, and ulcers of the mouth, throat, nose, genitals, and eyes. These severe rashes may be preceded by fever and flu-like symptoms [exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis];\u003cbr\u003e - extensive skin rash, high body temperature and swollen lymph nodes (DRESS syndrome);\u003cbr\u003e - extensive, red, scaly rash with bumps under the skin and blisters, accompanied by fever. Symptoms usually appear at the beginning of treatment (acute generalized exanthematous pustulosis);\u003cbr\u003e - chest pain, which may be a sign of a potentially serious allergic reaction called Kounis syndrome.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eCommon\u003c\/b\u003e (may affect up to 1 in 10 people): \u003cbr\u003emalaise, dizziness, fatigue.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eUncommon\u003c\/b\u003e (may affect up to 1 in 100 people):\u003cbr\u003e • increased stomach acidity (gastritis);\u003cbr\u003e • hypersensitivity reactions, such as skin rashes, urticaria, purpura, exanthema, pruritus, angioedema, asthma attacks, bronchospasm, dyspnoea (sometimes accompanied by low blood pressure);\u003cbr\u003e • insomnia, drowsiness;\u003cbr\u003e • anxiety;\u003cbr\u003e • reduced sensation in the legs and arms (paraesthesia);\u003cbr\u003e • congestion of the respiratory tract, cold (rhinitis);\u003cbr\u003e • breathing disorders (bronchospasm, dyspnea, apnea);\u003cbr\u003e • vision disorders;\u003cbr\u003e • ringing in the ears, impaired hearing, dizziness;\u003cbr\u003e • liver disorders (hepatitis, jaundice, impaired liver function);\u003cbr\u003e • skin sensitivity to light (photosensitivity);\u003cbr\u003e • kidney problems (impaired kidney function and toxic nephropathy in various forms, including interstitial nephritis, nephrotic syndrome and renal failure).\u003cbr\u003e   \u003cbr\u003e\u003cb\u003eRare\u003c\/b\u003e (may affect up to 1 in 1,000 people):\u003cbr\u003e • vision problems (optic neuritis, ocular alteration resulting in visual disturbances, toxic optic neuropathy);\u003cbr\u003e • depression, confusion, hallucinations;\u003cbr\u003e • lupus erythematosus syndrome;\u003cbr\u003e • reduction in the levels of platelets (thrombocytopenia), white blood cells (leukopenia, neutropenia, agranulocytosis), red blood cells (hemolytic anemia), reduction in the levels of all blood components (aplastic anemia);\u003cbr\u003e • inflammation of the brain membrane in the absence of bacterial infection (aseptic meningitis), especially if you have suffered from immune system disorders in the past (such as systemic lupus erythematosus or mixed connective tissue disease); this may manifest itself with symptoms such as headache, stiff neck, nausea, vomiting, fever, disorientation;\u003cbr\u003e • swelling due to fluid accumulation (edema).\u003cbr\u003e\u003cbr\u003e \u003cb\u003eVery rare\u003c\/b\u003e (may affect up to 1 in 10,000 people): \u003cbr\u003e• severe rash with blisters on the skin, especially on the legs, arms, hands and feet, which may spread to the face and lips (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis);\u003cbr\u003e • severe hypersensitivity reactions. Symptoms may include: facial edema, swelling of the tongue, swelling of the internal larynx with constriction of the airways, dyspnea, tachycardia, anaphylaxis, exfoliative and bullous dermatitis;\u003cbr\u003e • bothersome awareness of heartbeat (palpitations), heart failure, heart attack or high blood pressure, acute pulmonary edema, edema;\u003cbr\u003e • pancreatic disorders (pancreatitis);\u003cbr\u003e • liver failure.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eNot known\u003c\/b\u003e (frequency cannot be established based on available data) \u003cbr\u003e• a widespread, red, scaly rash with pustules under the skin and vesicles mainly located in the skin folds, trunk and upper limbs accompanied by fever at the start of treatment (acute generalized exanthematous pustulosis).\u003cbr\u003e Stop using Subitene if you develop these symptoms and contact your doctor immediately.\u003cbr\u003e See also paragraph 2.\u003cbr\u003e • Kounis syndrome.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eReporting of side effects\u003c\/b\u003e\u003cbr\u003e If you experience any side effects, including any not listed in this leaflet, talk to your doctor or pharmacist. You can also report side effects directly via the national reporting system at: \u003cu\u003ehttps:\/\/www.aifa.gov.it\/content\/segnalazionireazioni-avverse\u003c\/u\u003e .\u003cbr\u003e By reporting side effects you can help provide more information on the safety of this medicine.","brand":"FARMAKOPEA SPA","offers":[{"title":"Default Title","offer_id":53058143191374,"sku":"034764050","price":7.12,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0845\/6214\/9710\/files\/TE004-H0000484.jpg?v=1768783764","url":"https:\/\/farmaspeed.it\/en-eu\/products\/subitene-400-mg-granulato-per-soluzione-orale12-bustine","provider":"Farmaspeed","version":"1.0","type":"link"}