Name
FRONTLINE TRI-ACT SPOT-ON SOLUTION FOR DOGS 20-40 KG

Category
Ectoparasiticides for topical use.

Active ingredients
Each 4 ml pipette contains: fipronil: 270.4 mg, permethrin 2019.2 mg.

Directions
In dogs: For the treatment and prevention of flea and/or tick infestations where repellent (anti-feeding) activity against sandflies, horseflies and/or mosquitoes is required. Fleas: Treatment and prevention of Ctenocephalides felis flea infestations and prevention of Ctenocephalides canis flea infestations. One treatment prevents subsequent flea infestations for 4 weeks. The product can be used as part of a strategic treatment for flea allergy dermatitis, where this has been previously diagnosed by a veterinarian. Ticks: Treatment and prevention of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus). One treatment eliminates (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) and repels (Ixodes ricinus, Rhipicephalus sanguineus) ticks for 4 weeks after treatment and repels Dermacentor reticulatus for a period of 7 days up to 4 weeks after treatment. Mosquitoes and sandflies: repels (anti-feeding activity) sandflies (Phlebotomus perniciosus) for 3 weeks and mosquitoes (Culex pipiens, Aedes albopictus) for 4 weeks. Eliminates sandflies (Phlebotomus perniciosus) and mosquitoes (Aedes albopictus) for 3 weeks. Reduction of the risk of infection by Leishmania infantum carried by sandflies (Phlebotomus perniciosus) for up to 4 weeks. The effect is indirect due to the product's activity against the vector. Horseflies: repels (anti-feeding activity) and eliminates horseflies (Stomoxys calcitrans) for 5 weeks.

Dosage
For external use. The minimum recommended dose is 6.76 mg of fipronil/kg of body weight, and 50.48 mg/kg of permethrin equivalent to 0.1 ml of spot-on solution per kg of body weight. The use of the product is intended exclusively for the treatment of confirmed infestations or in the event of a risk of infestation by fleas and/or ticks, where repellent activity (antifeeding) against sandflies and/or mosquitoes and/or horseflies is also necessary. Repeated treatment may be indicated depending on exposure to ectoparasites. In these cases, the interval between two consecutive treatments should be at least 4 weeks. Method of administration: spot-on use. Choose the pipette of the appropriate size based on the weight of the dog. For dogs weighing more than 60 kg, use the correct combination of two pipette sizes, which corresponds as closely as possible to the body weight of the dog. The product should be applied to two points out of the dog's licking range of the application site. These points are at the base of the head and at the base of the neck between the shoulder blades. Remove the blisters from the packaging and separate one blister. Remove the pipette by cutting along the dotted line with a pair of scissors or tear open after bending the marked corner. Holding the pipette upright away from the face and body, cut the tip of the pipette with a pair of scissors to open it. Part the hair on the dog's back until the skin is visible. Place the tip of the pipette on the skin. Squeeze the pipette, applying approximately half of the contents to the base of the head. To empty the pipette, repeat the application at the base of the neck between the shoulder blades. For best results, ensure the product is applied directly to the skin and not the hair.

Conservation
Store in the original blister. Do not store above 25 degrees C.

Pregnancy and breastfeeding
Laboratory studies with fipronil and permethrin have not shown any teratogenic or embryotoxic effects. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. N-methylpyrrolidone, an excipient in the veterinary medicinal product, has been shown to be teratogenic in laboratory animals repeatedly exposed to high doses. Use only according to the benefit/risk assessment.