Description
Medical device useful for facilitating mobility, counteracting the physiological aging of connective tissue, whose primary therapeutic treatment consists of the following functions:
1. Barrier effect.
2. Lubricating activity.
3. Mechanical support in case of ongoing drug therapy.
The use of MD-TISSUE by qualified healthcare personnel in private or public healthcare facilities is recommended for:
- create a defense barrier against free radicals;
- counteract the physiological aging of connective tissue;
- relieve localized pain caused by movement.

How to use
MD-TISSUE can be used alone or in combination with all other medical devices belonging to the same line, in order to create a personalized treatment based on the individual clinical picture.
For use in the treatment of facial and neck wrinkles and firming of the subcutaneous connective tissue layer, MD-TISSUE should preferably be combined with MD-MATRIX (e.g. MD-TISSUE 2 vials, MD-MATRIX 1 vial/treatment).
The device can be used in patients requiring collagen supplementation or topical anti-aging treatment.

Therapeutic protocol :
2 treatments for the first 2 weeks, 1 treatment until symptoms improve (on average 8-10 sessions). If necessary, you can continue with 1 treatment every other week for a maximum of 10 sessions.
Chronic conditions: continue with 1 treatment per week for one month until symptoms improve, and then with 1 treatment per month.

• Intradermally: the application area must be aseptic;
Microinjections : insert the needle to a depth of 1-3 mm, perform microinjections of 0.2 ml – 0.3 ml in correspondence with the tissue to be treated.
Tunneling : 0.3 ml is applied along the wrinkle using the tunneling technique. Insert the needle almost tangentially along the entire length of the area, then inject and simultaneously withdraw the needle, while applying the product in a fan pattern.

• Periarticularly: the application area must be aseptic, insert the needle perpendicularly to the skin plane to a depth of 2-4 mm, perform microinjections of 0.3-0.5 ml.

Method of administration :
For this use of the medical device, the use of the following materials and accessories is recommended:
• Material to ensure skin asepsis: disposable glove, iodine-based solution, alcohol solution, sterile gauze, ethyl chloride-based skin spray.
• Microinjection needles: sterile 27 G, 4 mm.
• Tunneling needles: sterile 30G, 13mm.
• Syringes: 5 or 10 cc, depending on the quantity of solution to be injected.

Components
Collagen of porcine origin.
Excipients: ascorbic acid, magnesium gluconate, pyridoxine hydrochloride, riboflavin, thiamine hydrochloride, NaCl, water for injection.

Warnings
Disposable.
No case of hypersensitivity has been reported.
Contains collagen of animal origin from porcine species. Patients with known hypersensitivity to the component or excipients must first undergo an injection test in the arm and be kept under observation for one hour.
Slight redness at the injection area may be due to the mechanical effect of the needle or a skin reaction.
The application may cause burning/pain symptoms at the injection sites, which generally resolve within 5-10 minutes after the end of treatment.
Skin cleaning/disinfection is required before and after application.
Any pyogenic bacteria may produce an abscess in the injection area.
Keep out of the reach and sight of children.
Do not use after expiration.
Use the product immediately after opening.
Do not use if seal is broken or tampered with.
After opening, the contents of the vial must be injected immediately.
Do not use if packaging is damaged.

Conservation
Store at a temperature between 2°C and 30°C, protect from sunlight and frost.
The expiry date refers to the product in its intact packaging, stored correctly.

Format
Pack of 5 sterile 2 ml vials