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ZERINOL "300 MG + 2 MG COATED TABLETS" 20 TABLETS"
Descrizione Prodotto
€13,20
-20%
€10,56
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€10,56
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+39 0863 599589
366 2291710
Descrizione
Pagamenti
Spedizioni
Name
Zerinol 300 mg + 2 mg coated tablets
Paracetamol + Chlorphenamine maleate
What it is and what it is used for
Zerinol is an analgesic (pain reliever) and antipyretic (fever reducer) that contains the active ingredients paracetamol and chlorphenamine maleate.
Zerinol is used to treat cold and flu symptoms in adults.
Contact your doctor if you do not feel better or if you feel worse after 3 days.
What you need to know before taking the medicine
Do not take Zerinol
- if you are allergic to paracetamol or chlorphenamine maleate or any of the other ingredients of this medicine (listed in section 6) or to other antihistamines (substances similar to chlorphenamine, i.e. medicines used to treat allergies);
- during pregnancy and breastfeeding;
- if you suffer from severe haemolytic anaemia (a disease caused by the destruction of red blood cells);
- if you have a deficiency of a certain enzyme called glucose-6-phosphate dehydrogenase, the lack of which can cause haemolytic anaemia;
- if you suffer from severe hepatocellular insufficiency (disease associated with alteration of liver function);
- if you suffer from glaucoma (an eye disease often associated with increased fluid pressure within the eye);
- in case of prostatic hypertrophy (disease characterized by an increase in the volume of the prostate);
- in case of bladder neck obstruction (urinary bladder obstruction);
- in case of pyloric, duodenal and other gastrointestinal tract stenosis (gastrointestinal diseases characterized by narrowing of specific parts of the digestive tract);
- in case of urogenital stenosis (narrowing of the urinary and reproductive organs);
- if you are or have been treated in the previous two weeks with monoamine oxidase inhibitors (MAOIs) (see section "Other medicines and Zerinol").
Warnings and precautions
Talk to your doctor or pharmacist before taking Zerinol.
In case of glucose-6-phosphate dehydrogenase (G6PD) deficiency (may lead to haemolytic anaemia) You should not take this medicine for more than 3 consecutive days without consulting your doctor.
After a short period of treatment without appreciable results, consult your doctor. If you have a fever for more than three days, or if the symptoms do not improve or new symptoms appear within three days, or are accompanied by high fever, exanthema (skin rashes accompanied by redness of the skin), excessive amount of mucus and persistent cough, consult your doctor who will establish the correct diagnosis.
Paracetamol
During treatment with paracetamol, before taking any other medicine, you must check that it does not contain paracetamol, since if paracetamol is taken in high doses, serious side effects may occur (see also the section "If you take more Zerinol than you should").
Also, before combining any other medicine, contact your doctor (see also the paragraph "Other medicines and Zerinol").
Before starting therapy with Zerinol, do not take any medicines whose combined use is not recommended (see paragraph "Other medicines and Zerinol").
High or prolonged doses of the product can cause hepatopathy (liver disease) which is high risk for you (see also the paragraph "If you take more Zerinol than you should") and alterations to the kidneys and blood which may be serious.
Serious skin reactions: Life-threatening skin reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), fixed drug eruption and exfoliative dermatitis have been reported with the use of paracetamol. If symptoms or signs of these serious skin reactions occur (e.g. progressive skin redness associated with blisters or mucosal lesions), stop treatment with Zerinol immediately and contact the nearest hospital.
During treatment with Zerinol, tell your doctor immediately if:
If you have serious illnesses, including severe kidney failure or sepsis (when bacteria and their toxins circulate in the blood causing organ damage) or malnutrition, chronic alcoholism or if you are also taking flucloxacillin (an antibiotic). A serious condition called metabolic acidosis (an abnormality of the blood and fluids) has been reported in patients in these situations when paracetamol is used at regular doses over a long period or when paracetamol is taken in combination with flucloxacillin. Symptoms of metabolic acidosis may include: severe breathing difficulties with rapid deep breathing, drowsiness, nausea and vomiting.
tion to flucloxacillin. Symptoms of metabolic acidosis may include: severe breathing difficulties with rapid, deep breathing, drowsiness, nausea, and vomiting.
episodes with rapid deep breathing, drowsiness, nausea and vomiting.
Use caution with Zerinol if you are allergic to aspirin and/or nonsteroidal anti-inflammatory drugs (NSAIDs).
Since serious allergic reactions to paracetamol have been observed (e.g. anaphylactic shock, see also the section "Possible side effects"), at the first signs of an allergic reaction following the use of Zerinol, stop treatment and consult your doctor.
Zerinol should be used with caution and after medical evaluation in case of chronic alcoholism, excessive alcohol intake (3 or more alcoholic drinks per day), eating disorders (anorexia, bulimia, cachexia, chronic malnutrition), dehydration, decreased circulating blood volume (hypovolemia), liver diseases such as mild to moderate liver failure and Gilbert's syndrome, severe renal failure.
Chlorphenamine Maleate
Zerinol contains an antihistamine (chlorphenamine). At the doses normally taken, antihistamines have side effects that vary greatly from person to person and from drug to drug and must be used with caution in people who suffer from high blood pressure, heart disease or thyroid disease. The most frequent side effect is sedation (physical and mental relaxation) which may manifest itself with drowsiness (see also the paragraphs "Driving and using machines" and "Side effects"). Children and the elderly are more exposed to this type of side effect.
Chlorphenamine may induce photosensitivity (allergic skin reaction following exposure to light). Patients with renal or hepatic (liver) insufficiency: if you have renal insufficiency or mild-moderate hepatic insufficiency, use this medicine with caution.
Elderly: Due to their greater sensitivity to the drug, the elderly should adhere to the indicated dosages. In elderly patients treated with antihistamines, effects such as dizziness, sedation, confusion and hypotension may occur with greater probability. Elderly patients are particularly sensitive to the anticholinergic side effects of antihistamines such as dry mouth, constipation and urinary retention (especially in men).
Elderly patients with mental disorders (such as confusion, delirium, dementia, impairment of cognitive abilities such as memory and reasoning) should avoid the use of Zerinol due to adverse effects on the central nervous system.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
For the following side effects, the frequency cannot be established based on the available data (frequency not known).
Serious condition which can make the blood more acidic (called metabolic acidosis), in patients with a serious illness who use paracetamol (see section 2).
If you experience any of the following symptoms, STOP using Zerinol immediately and contact your doctor or the nearest hospital where you will be given appropriate and specific treatment:
- serious skin reactions manifested by skin rash, some of them fatal (including Stevens-Johnson syndrome and toxic epidermal necrolysis, acute generalized exanthematous pustulosis);
- allergic reactions such as:
- angioedema (sudden swelling of the skin or mucous membranes);
- laryngeal edema (swelling of the larynx);
- anaphylactic shock (severe allergic reaction).
Side effects affecting the blood :
- thrombocytopenia (reduction in the number of platelets in the blood);
- neutropenia (reduction in the number of neutrophils in the blood);
- leukopenia (reduction in the number of white blood cells in the blood);
- haemolytic anaemia (decrease in the amount of haemoglobin and red blood cells), particularly in patients with glucose-6-phosphate dehydrogenase deficiency;
- agranulocytosis (reduction in the number of granulocytes in the blood);
- pancytopenia (reduction in the number of all cells in the blood);
- excess acid in the blood due to the presence of too much pyroglutamic acid resulting from low levels of glutathione.
Nervous system disorders such as:
- sedation;
- drowsiness;
- asthenia (weakness);
- vertigo (dizziness);
- headache (headache);
- inability to concentrate;
- abnormal coordination;
- confusion.
Skin reactions of various types and severity have been reported with the use of paracetamol, including cases of:
- rash (skin eruption);
- urticaria (appearance of red spots on the skin);
- serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), fixed drug eruption and exfoliative dermatitis;
- photosensitization (allergic skin reaction following exposure to light).
Other side effects may include:
- blurred vision;
- mydriasis (dilation of the pupil);
- thickening of bronchial secretions (thicker mucus), bronchospasm (temporary narrowing of the airways);
- dry mouth, nausea, gastrointestinal disturbances;
- alterations in liver function and hepatitis (liver inflammation);
- kidney changes: acute renal failure (reduction of kidney function), interstitial nephritis (inflammation of the kidneys), hematuria (presence of blood in the urine), anuria (absence of urine), urinary retention (difficulty in passing urine);
- psychiatric disorders: confusion, nightmares, depression;
- heart changes: tachycardia (increased heart rate), palpitations;
- orthostatic hypotension (excessive decrease in blood pressure when standing up);
- ear disorder: tinnitus.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system at: https://www.aifa.gov.it/content/segnalazionireazioni-avverse .
By reporting side effects you can help provide more information on the safety of this medicine.
Zerinol 300 mg + 2 mg coated tablets
Paracetamol + Chlorphenamine maleate
What it is and what it is used for
Zerinol is an analgesic (pain reliever) and antipyretic (fever reducer) that contains the active ingredients paracetamol and chlorphenamine maleate.
Zerinol is used to treat cold and flu symptoms in adults.
Contact your doctor if you do not feel better or if you feel worse after 3 days.
What you need to know before taking the medicine
Do not take Zerinol
- if you are allergic to paracetamol or chlorphenamine maleate or any of the other ingredients of this medicine (listed in section 6) or to other antihistamines (substances similar to chlorphenamine, i.e. medicines used to treat allergies);
- during pregnancy and breastfeeding;
- if you suffer from severe haemolytic anaemia (a disease caused by the destruction of red blood cells);
- if you have a deficiency of a certain enzyme called glucose-6-phosphate dehydrogenase, the lack of which can cause haemolytic anaemia;
- if you suffer from severe hepatocellular insufficiency (disease associated with alteration of liver function);
- if you suffer from glaucoma (an eye disease often associated with increased fluid pressure within the eye);
- in case of prostatic hypertrophy (disease characterized by an increase in the volume of the prostate);
- in case of bladder neck obstruction (urinary bladder obstruction);
- in case of pyloric, duodenal and other gastrointestinal tract stenosis (gastrointestinal diseases characterized by narrowing of specific parts of the digestive tract);
- in case of urogenital stenosis (narrowing of the urinary and reproductive organs);
- if you are or have been treated in the previous two weeks with monoamine oxidase inhibitors (MAOIs) (see section "Other medicines and Zerinol").
Warnings and precautions
Talk to your doctor or pharmacist before taking Zerinol.
In case of glucose-6-phosphate dehydrogenase (G6PD) deficiency (may lead to haemolytic anaemia) You should not take this medicine for more than 3 consecutive days without consulting your doctor.
After a short period of treatment without appreciable results, consult your doctor. If you have a fever for more than three days, or if the symptoms do not improve or new symptoms appear within three days, or are accompanied by high fever, exanthema (skin rashes accompanied by redness of the skin), excessive amount of mucus and persistent cough, consult your doctor who will establish the correct diagnosis.
Paracetamol
During treatment with paracetamol, before taking any other medicine, you must check that it does not contain paracetamol, since if paracetamol is taken in high doses, serious side effects may occur (see also the section "If you take more Zerinol than you should").
Also, before combining any other medicine, contact your doctor (see also the paragraph "Other medicines and Zerinol").
Before starting therapy with Zerinol, do not take any medicines whose combined use is not recommended (see paragraph "Other medicines and Zerinol").
High or prolonged doses of the product can cause hepatopathy (liver disease) which is high risk for you (see also the paragraph "If you take more Zerinol than you should") and alterations to the kidneys and blood which may be serious.
Serious skin reactions: Life-threatening skin reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), fixed drug eruption and exfoliative dermatitis have been reported with the use of paracetamol. If symptoms or signs of these serious skin reactions occur (e.g. progressive skin redness associated with blisters or mucosal lesions), stop treatment with Zerinol immediately and contact the nearest hospital.
During treatment with Zerinol, tell your doctor immediately if:
If you have serious illnesses, including severe kidney failure or sepsis (when bacteria and their toxins circulate in the blood causing organ damage) or malnutrition, chronic alcoholism or if you are also taking flucloxacillin (an antibiotic). A serious condition called metabolic acidosis (an abnormality of the blood and fluids) has been reported in patients in these situations when paracetamol is used at regular doses over a long period or when paracetamol is taken in combination with flucloxacillin. Symptoms of metabolic acidosis may include: severe breathing difficulties with rapid deep breathing, drowsiness, nausea and vomiting.
tion to flucloxacillin. Symptoms of metabolic acidosis may include: severe breathing difficulties with rapid, deep breathing, drowsiness, nausea, and vomiting.
episodes with rapid deep breathing, drowsiness, nausea and vomiting.
Use caution with Zerinol if you are allergic to aspirin and/or nonsteroidal anti-inflammatory drugs (NSAIDs).
Since serious allergic reactions to paracetamol have been observed (e.g. anaphylactic shock, see also the section "Possible side effects"), at the first signs of an allergic reaction following the use of Zerinol, stop treatment and consult your doctor.
Zerinol should be used with caution and after medical evaluation in case of chronic alcoholism, excessive alcohol intake (3 or more alcoholic drinks per day), eating disorders (anorexia, bulimia, cachexia, chronic malnutrition), dehydration, decreased circulating blood volume (hypovolemia), liver diseases such as mild to moderate liver failure and Gilbert's syndrome, severe renal failure.
Chlorphenamine Maleate
Zerinol contains an antihistamine (chlorphenamine). At the doses normally taken, antihistamines have side effects that vary greatly from person to person and from drug to drug and must be used with caution in people who suffer from high blood pressure, heart disease or thyroid disease. The most frequent side effect is sedation (physical and mental relaxation) which may manifest itself with drowsiness (see also the paragraphs "Driving and using machines" and "Side effects"). Children and the elderly are more exposed to this type of side effect.
Chlorphenamine may induce photosensitivity (allergic skin reaction following exposure to light). Patients with renal or hepatic (liver) insufficiency: if you have renal insufficiency or mild-moderate hepatic insufficiency, use this medicine with caution.
Elderly: Due to their greater sensitivity to the drug, the elderly should adhere to the indicated dosages. In elderly patients treated with antihistamines, effects such as dizziness, sedation, confusion and hypotension may occur with greater probability. Elderly patients are particularly sensitive to the anticholinergic side effects of antihistamines such as dry mouth, constipation and urinary retention (especially in men).
Elderly patients with mental disorders (such as confusion, delirium, dementia, impairment of cognitive abilities such as memory and reasoning) should avoid the use of Zerinol due to adverse effects on the central nervous system.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
For the following side effects, the frequency cannot be established based on the available data (frequency not known).
Serious condition which can make the blood more acidic (called metabolic acidosis), in patients with a serious illness who use paracetamol (see section 2).
If you experience any of the following symptoms, STOP using Zerinol immediately and contact your doctor or the nearest hospital where you will be given appropriate and specific treatment:
- serious skin reactions manifested by skin rash, some of them fatal (including Stevens-Johnson syndrome and toxic epidermal necrolysis, acute generalized exanthematous pustulosis);
- allergic reactions such as:
- angioedema (sudden swelling of the skin or mucous membranes);
- laryngeal edema (swelling of the larynx);
- anaphylactic shock (severe allergic reaction).
Side effects affecting the blood :
- thrombocytopenia (reduction in the number of platelets in the blood);
- neutropenia (reduction in the number of neutrophils in the blood);
- leukopenia (reduction in the number of white blood cells in the blood);
- haemolytic anaemia (decrease in the amount of haemoglobin and red blood cells), particularly in patients with glucose-6-phosphate dehydrogenase deficiency;
- agranulocytosis (reduction in the number of granulocytes in the blood);
- pancytopenia (reduction in the number of all cells in the blood);
- excess acid in the blood due to the presence of too much pyroglutamic acid resulting from low levels of glutathione.
Nervous system disorders such as:
- sedation;
- drowsiness;
- asthenia (weakness);
- vertigo (dizziness);
- headache (headache);
- inability to concentrate;
- abnormal coordination;
- confusion.
Skin reactions of various types and severity have been reported with the use of paracetamol, including cases of:
- rash (skin eruption);
- urticaria (appearance of red spots on the skin);
- serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), fixed drug eruption and exfoliative dermatitis;
- photosensitization (allergic skin reaction following exposure to light).
Other side effects may include:
- blurred vision;
- mydriasis (dilation of the pupil);
- thickening of bronchial secretions (thicker mucus), bronchospasm (temporary narrowing of the airways);
- dry mouth, nausea, gastrointestinal disturbances;
- alterations in liver function and hepatitis (liver inflammation);
- kidney changes: acute renal failure (reduction of kidney function), interstitial nephritis (inflammation of the kidneys), hematuria (presence of blood in the urine), anuria (absence of urine), urinary retention (difficulty in passing urine);
- psychiatric disorders: confusion, nightmares, depression;
- heart changes: tachycardia (increased heart rate), palpitations;
- orthostatic hypotension (excessive decrease in blood pressure when standing up);
- ear disorder: tinnitus.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system at: https://www.aifa.gov.it/content/segnalazionireazioni-avverse .
By reporting side effects you can help provide more information on the safety of this medicine.
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Bank details: BNL BNP PARIBAS BANK - Branch No. 3646 AVEZZANO IN THE NAME OF: STORNELLI FARMACY SNC OF DR. FRANCA STORNELLI & C REASON: ORDER NUMBER IBAN IT87D0100540440000000018373 |
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NOTA BENE: le informazioni presenti nelle schede prodotto che potrete consultare in questo sito non devono essere interpretate come consulenza medica e non intendono, né possono sostituire le prescrizioni mediche. Le immagini, se presenti, sono fornite al solo scopo illustrativo e non costituiscono elemento identificativo.