Name
ADVANTIX SPOT-ON FOR DOGS UP TO 4 KG

Category
Ectoparasiticides, insecticides and repellents.

Active ingredients
Each 0.4 ml pipette contains Imidacloprid: 40.0 mg. Permethrin (40/60): 200.0 mg. Excipient(s): Butylhydroxytoluene (E321): 0.4 mg. For the full list of excipients, see section 6.1.

Directions
For the treatment and prevention of flea infestations (Ctenocephalides canis, Ctenocephalides felis). Fleas on dogs are killed within one day of treatment. One treatment prevents further flea infestations for four weeks. The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). For the treatment of lice (Trichodectes canis). The product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for four weeks, and Dermacentor reticulatus for three weeks). Through its repellent and knockdown action on the Rhipicephalus sanguineus tick vector, the product reduces the likelihood of transmission of the pathogen Erlichia canis, thereby reducing the risk of canine ehrlichiosis. The risk reduction has been demonstrated in studies from the third day after application of the product and persists for 4 weeks. Ticks already present on the dog may not be killed within two days after treatment and may remain attached and visible. It is therefore recommended that ticks already present on the dog be removed at the time of treatment to prevent them from attaching and taking a blood meal. One treatment provides repellent (anti-feeding) activity against sand flies (Phlebotomus papatasi for two weeks and Phlebotomus perniciosus for three weeks), mosquitoes (Aedes aegypti for two weeks and Culex pipiens for four weeks) and horse flies (Stomoxys calcitrans) for four weeks. Reduction of the risk of infection with Leishmania infantum via transmission by sand flies (Phlebotomus perniciosus) for up to 3 weeks. The effect is indirect and determined by the activity of the product against the vector.

Dosage
The minimum recommended dose is: 10 mg/kg body weight (bw) imidacloprid and 50 mg/kg body weight (bw) permethrin. Dosage schedule for Advantix Spot-on. Dogs (kg body weight): <= 4 kg; Trade name: advantix spot-on for dogs up to 4 kg; volume: 0.4 ml; imidacloprid: minimum 10 mg/kg body weight; permethrin: minimum 50 mg/kg body weight. Dogs (kg body weight): >4 kg <= 10 kg; Trade name: advantix spot-on for dogs over 4 kg and up to 10 kg; volume: 1.0 ml; imidacloprid: 10 - 25 mg/kg body weight; permethrin: 50 - 125 mg/kg body weight. Dogs (kg body weight): >10 kg <= 25 kg; Trade name: advantix spot-on for dogs over 10 kg and up to 25 kg; volume: 2.5 ml; imidacloprid: 10 - 25 mg/kg body weight; permethrin: 50 - 125 mg/kg body weight. Dogs (kg body weight): >25 kg <= 40 kg; Trade name: advantix spot-on for dogs over 25 kg up to 40 kg; volume: 4.0 ml; imidacloprid: 10 - 16 mg/kg body weight; permethrin: 50 - 80 mg/kg body weight. To reduce re-infestation due to the appearance of new fleas, it is recommended to treat all dogs in the household. Other animals living in the same household should be treated with a suitable product. To further help reduce the environmental threat, the additional use of a suitable environmental treatment against adult fleas and their developing stages is recommended. The product remains effective if the animal gets wet. However, prolonged and intense exposure to water should be avoided. Frequent exposure to water may reduce the persistence of efficacy. In such cases, do not repeat the treatment more frequently than once a week. If shampooing is required for the dog, it is best to do so before applying Advantix or at least two weeks after application to optimise the efficacy of the product. In the event of lice infestation, a further veterinary examination is recommended 30 days after treatment, as some animals may require a second treatment. To protect a dog throughout the sandfly season, treatment should be continued as prescribed throughout. For cutaneous use only. Apply only to intact skin. Method of administration for pipettes with a short applicator tip: Remove a pipette from the packaging. Holding the pipette upright, twist and remove the cap. Turn the cap back over and replace the opposite end on the pipette. Twist the cap to break the seal and then remove the cap from the pipette. For dogs 10 kg body weight or less: With the dog standing on all fours, part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times until the contents are emptied directly onto the skin. For dogs over 10 kg body weight: With the dog standing on all fours, the entire contents of the Advantix pipette should be applied equally to four spots on the top of the back from the shoulders to the base of the tail. At each spot, part the coat until the skin is visible. Place the tip of the pipette on the skin and squeeze gently to empty some of the solution onto the skin. Do not apply too much solution to any spot which could cause some of the solution to run down the dog's sides. Method of administration for pipettes with a long applicator tip: Remove one pipette from the package. Holding the pipette upright, twist and remove the cap. For dogs weighing 10 kg or less: With the dog standing on all fours, part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times until the contents are emptied directly onto the skin. For dogs weighing over 10 kg: With the dog standing on all fours, apply the entire contents of the Advantix pipette equally to four spots on the top of the back from the shoulders to the base of the tail. At each spot, part the coat until the skin is visible. Place the tip of the pipette on the skin and squeeze gently to empty some of the solution onto the skin. Do not apply too much solution to any spot which may cause some of the solution to run down the dog's sides.

Conservation
Do not freeze. Pipette with short applicator tip: After opening the foil pouch, store in a dry place at a temperature not exceeding 30 degrees C. Pipette with long applicator tip: After opening the foil pouch, the product should be applied to the dog's skin. Pipette with short applicator tip (pipettes in blister packs in pouch). Shelf life of the veterinary medicinal product packaged in the foil pouch: 5 years. Shelf life of the product after opening the foil pouch: 2 years (all pipettes should be used within 2 years after opening the foil pouch or before the expiry date stated on the pipette, whichever is shorter). Shelf life of the opened pipette: Not applicable. Once opened, the entire contents of the pipette should be applied to the animal's skin. Pipette with long applicator tip (in individual pouches). Shelf life of the product in the foil pouch: 3 years. Shelf life of the opened pipette: Not applicable. Once opened, the entire contents of the pipette must be applied to the dog's skin.

Pregnancy and breastfeeding
It can be used during pregnancy and breastfeeding.