Description
Normociclo tablets are a food supplement with a strong diuretic activity to combat water retention and cellulite blemishes, and a regulatory activity on the hormonal balance of women to improve disorders related to premenstrual syndrome and climacteric (hot flashes).

Property
Ortosifon : a plant rich in antioxidants is a powerful natural diuretic. It increases the elimination of sodium, chlorine and uric acid, counteracting water retention. It is considered a slimming food supplement because it promotes the concentration of cholesterol in the liver, reducing blood levels. It is also recommended in the treatment of urinary tract inflammation. The effects of the plant are attributable to the presence of lipophilic flavonoids such as sinensetin.
Pilosella : it is mainly a powerful diuretic that is used in the treatment of cellulite blemishes, ankle swelling, edema in the lower limbs, water retention especially if resulting from eating disorders or pharmacological treatments. It has a choleretic and cholagogue action that contributes to liver detoxification. An anti-inflammatory effect is also attributed to the plant, in fact it inhibits the enzyme phospholipase A2 which normally, if activated, releases the precursors of inflammation. The presence of chlorogenic acid, present in the plant, has slimming properties as it inhibits the release of hepatic glucose by shifting the metabolism towards the use of fats from adipose tissue to produce energy. Due to the presence of tannins, substances with antibiotic action, it is particularly useful as an adjuvant in cystitis.
Bromelain from pineapple : is an enzyme with draining activity used in the treatment of cellulite. Its proteolytic, anti-inflammatory, anti-edema and anticoagulant properties are used to combat orange peel skin and swelling that mainly affects the lower limbs. Bromelain is able to reduce tissue inflammation and dissolve edema caused by fluid retention, typical symptoms of the presence of cellulite or localized adiposity.
Magnesium oxide : it is a hygroscopic mineral, that is, capable of attracting large quantities of liquids. In association with orthosiphon, also called Java tea, it has an important purifying action, promoting the elimination of liquids and also improving intestinal function, acting as an osmotic laxative. The combination of magnesium oxide and orthosiphon is very useful for combating the unsightly appearance of cellulite caused by water retention, a problem that is often found in those who use the contraceptive pill, or the feeling of swelling that accompanies many women in the premenstrual period. Furthermore, magnesium has a beneficial action on the muscles, counteracting stiffness and improving resistance to fatigue.
Curcuma longa root : contains an active substance, curcumin, which can reduce the absorption of sugars, thus controlling blood sugar levels. This helps avoid the so-called glycemic peaks that cause increased production of insulin, the hormone that, by signaling the presence of excess sugar to the brain, causes a slowdown in metabolism and the formation of fat reserves. It stimulates bile secretion and the release of bile, thus the elimination of toxins through the feces by increasing intestinal peristalsis. In this way, the metabolization of fats and the reduction of blood cholesterol levels are also promoted. Integration with turmeric, within a slimming diet, helps the loss of excess body weight. Turmeric also has a powerful anti-inflammatory, anti-radical and hepatoprotective action.
Chaste tree (Vitex agnus castus) : it is used to harmonize the hormonal balance of women, regulating the ovulatory system in the presence of amenorrhea and dysmenorrhea, and improving neurovegetative disorders such as hot flashes in menopause. It slows the release of prolactin, a hormone that determines the stimulation of the mammary gland, in some circumstances responsible for mastalgia. It seems to act on the rebalancing of the estrogen/progesterone ratio in favor of the latter (the decrease in this ratio in favor of estrogen, common in premenopause, can cause swelling of the breasts or abdomen, menstrual disorders, infertility and weight gain). It is therefore indicated in premenstrual syndrome (with its physical and psychological manifestations), amenorrhea, hypermenorrhea, polymenorrhea, neuralgic pain in the breasts, in vasomotor disorders of the climacteric (hot flashes).

Ingredients
Orthosiphon, pilosella, bromelain, curcuma longa root, chaste tree, magnesium oxide.

Gluten free (less than 20 ppm).

How to use
Take 1 tablet in the morning and 1 in the evening, away from meals.

Warnings
Avoid taking the product in case of known hypersensitivity to one or more components and in patients who present edema caused by renal and/or cardiac insufficiency.

Conservation
Store in a cool, dry place, away from light and heat sources. Consume by the date shown on the package. The expiry date refers to the product in its intact packaging and stored correctly.
Validity with intact packaging: 36 months.

Format
Pack of 30 tablets of 1.15 g.

Bibliography
1. Proksch P. orthosiphon aristatus (Blume) Miquel-der Katzenbart.Pflanzeninhaltsstoue und ihre potentielle diuretische Wirkung. Z Phytoterapie 1992; 13:63-9.
2. Lauritzen C, Reuter HD, Repges R, Bohnert KJ, Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomedicine 1997;4:183-9.
3. Barunk. Bromelain: an overview natural product radiance 2008.
4. Curcumawurzelstock-curcumae longae rhizome. Deutscher Arzneimittel-Codex.
5. Staesche K, Schleinitz H. Turmeric.In:Hansel R, Keller K, Rimpler H, Schneider G, editors. Hagers Handbuch der Pharmazeutischen Praxis, 5th ed. Volume 4; Drogen AD. Berlin-Heidelberg-New York-London: Springer-Verlag, 1992:1084-102.
6. Schwartz R, Spencer H & Welsh JJ (1984) - Magnesium absorption in human subjects from leafy vegetables, intrinsically labeled with stable - Mg. Am. J. Clin. Nutr., 39: 571-76.
7. Mercier F, Mercier LJ. Orthosiphon stamineus, a hepatorenal medicine. Stimulant of urinary purification. Medical Bulletin 1936:523-31.