Description
Sterile solution.
Highly hygienic Tris-EDTA + N-Acetyl Cysteine ​​(NAC) buffer for dogs and cats.
Tris-EDTA (Ethylene Diammine Tetracetic Acid) has bactericidal activity on non-growing bacteria located within the biofilm ( Ciofu et al, 2017 ); in association with Tromethamine (Tris) it damages the bacterial cell walls and increases penetration into the bacterial membranes; it is well tolerated and non-ototoxic; it acts in synergy with chlorhexidine ( Guardabassi et al, 2010 ). Recently, an in vitro work has demonstrated that Tris-EDTA is a more than effective adjunct in the treatment of chronic cases of Pseudomonas otitis media with the presence of potential biofilms combined with antibiotics ( Pye et al, 2014 ).
NAC is an N-acetylated derivative of the amino acid cysteine. It has mucolytic properties, thus inhibiting the production of exopolysaccharides, thereby weakening the EPS matrix. It has recently been used in eight clinical studies as an adjuvant treatment to destroy mature biofilm and prevent its formation, and has demonstrated an excellent safety and efficacy profile.
The combination of Tris-EDTA and NAC on the skin and ear before the application of topical products such as chlorhexidine, antibiotics, and synthetic antimicrobial peptides therefore allows for an increase in the permeability of the mature biofilm and, consequently, its disintegration, effectively helping to overcome the problem of resistance to classic antibacterial therapeutic approaches.

How to use
1. Apply pressure to the top of the bottle until the cap breaks completely.
2. Shake the bottle.
3. Use the syringe inside the package to draw the quantity to be used according to the instructions of the Veterinarian.
In the ear canal: irrigate adequately and massage at the base of the ear.
On the skin: spray until the affected area is completely soaked.
Repeat treatment as needed or as directed by your veterinarian.

Format
120 ml bottle.

Cod. PP3310001